I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. Also I read on Dr Mercola site that heartworms is in the dogs blood not the digestive track and garlic won't work. All medicines come with some potential risks and side effects, and pet owners should weigh the potential risks and benefits in consultation with a veterinarian. I do believe it caused her blindness. I've sent this thread and loads of other information to my vet and zoetis. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. Very "out of it". In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. I am currently in the same situation and we are at day 16 after giving simparica. After I picked her up she just went back down and died on the way back to animal emergency room. Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. This sounds so scary. Daily Paws is part of the Meredith National Digital Network. and now i'm on an hour by hour let's see if she will perk up. Contrary to the statement in that same above article "The results are fatal for fleas and ticks but safe for mammals such as your dog." Neurological reactions: In rare cases, dogs may exhibit tremors, ataxia (loss of coordination), or seizures as a side effect of the medication. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. I dont like the idea if ingestible medicine that kills fleas. so what about her puppies I am so worried. It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. Took her to her Vet where I was told she had another tremor. Don't risk the well-being of your beloved dog just because something is more convenient. Most common is vomitting. Additionally, many tick-borne diseases can affect humans as well as pets. Simparica Trio is just one of many parasite prevention products on the market for dogs. Also feed bland diet- rice, ground beef, chicken, cottage cheese. If anyone has discovered what can help please let me know. I am hopeful he will make it through the next few weeks. He now cannot go in the car anymore. He just isnt himself. Today shes acting better, finally, but her back legs are still collapsing and she is weak. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. But this month we are at day 7 and I expect the diarrhea it to continue. When my puppy was 2 months old he was "gifted" his first dose of Simparica Trio from his vet. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. Stopped meds and he has had 3 more seizures since. Vet says garlic doesn't work and obviously it didn't because he shaved a little of dogs fur and put it on a paper towels and it was full of fleas.The vet gives me Simpirica-ok fleas are dropping off him like crazy. Then she started having tremors. I made some chicken and rice. We trusted our Vet when he recommended this over Revolution topical anti-tic/flea medication. She's a Brittany (Spaniel). Today she has fallen 2 or 3 times in the last 8 hours). I thought it was them not liking the food and made a change. Is the added expense worth the trouble to insure your beloved pet? My French bulldog 2 years olds had a second attack in 3 days. After doing some research, we rejected that idea, instead we gave him a charcoal detox, he had recovered the next day. Sarolaner is ingested by fleas and ticks when they bite, and works by over-exciting their nervous system, causing paralysis and death. She gave her a shot to keep her from throwing up and took her x-rays and told me to come back the next day if she wasn't better. Im switching back to the protection he used before Simparica Trio. My vet recommended this for my puppy, he is now lethargic, has blood in stool, and can hardly stay awake. They immediately denied they were in the wrong for prescribing because any meds can have side effects but Im convinced this medication is poison. I just gave him heartgard and nexgard about 2 weeks with no issues. Yesterday one baby threw up four times within one hour of taking her chewable. Use with caution in dogs with a history of seizures or neurologic disorders. this link is to an external site that may or may not meet accessibility guidelines. We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects. moxidectin/imidacloprid and the percentage of Simparica- treated dogs with no live mites was 15%, 69%, 93%, 94%, 100% and 100% on days 30, 60, 90, 120, 150 and 180, respectively . Shes now in the Er. Did you go to the vets or not? My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. He is pissing a lot and often and drinking a lot of water. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. I put water with electrolytes by his cage & food . For all symptoms to be reversed & to return to normal . Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. The following day she got diarrhea and was extreemly quiet. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. I will do anything to stop this from hurting or killing anyone else's baby. I not any kind of a medical doctor nor am I a vet however I do often research many topics on health related matters both canine and human for decades and then use my common sense to draw logical conclusions or make reasonable guesses. Our dog has not been given another dose. gave this to my dog three different times. He is 5 months old. he didn't throw up but he doesn't want to go to bed at night and he just paces around the bedroom and sometimes goes under the bed. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. All content contained in this article is sourced from public sources or the manufacturer. Has started to stumble and sleeps 10 to 12 hours at a time. Pyrantel only treats parasites found in the gastrointestinal tract because it does not absorb well into the bloodstream. The day after administering drug he had two incapacitating seizures. Yea so what about the 10 percent? Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. How is ur puppy? I lost my dog due to Simparica Trio. So new pup goes on garlic tabs-as he growing I'm upping the amount because I wanted him to be protected. If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. It's important for your dog to be tested for heartworm disease before starting Simparica Trio (or any other heartworm prevention) because it will not kill adult heartworms and can actually worsen your dog's condition. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. I got my dog Josey up to let him out to pee. I left a lot out but didnt want to make too lengthy post. He drank not crazy about dog food . Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. I used to use revolution but they dont cover ticks as well. She has been taking Trifexis for years with no problem. That sh-t should be banned. We will have blood work and results this evening. She was being seen by her regular vet and was put on antibiotics. He has been resting most of the day so far, thankfully no seizures.. but I promise I will not be giving him the other 2 doses I got from the vet after reading all of the experiences everyone else has had with their animals. I'm so sorry. He has bad allergies and oral works best. Any advice on the diarrhea? Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. He has been barking a lot more than he used to. Im certain that its the simparica. Any suggestion? The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. Simparicaworks by impacting the nervous system of invertebrates such as fleas and ticks. He has no appetite. Random vomitting is no fun either. If only one percent of dogs have reaction to these drugs and 100,000 pups are given the drugs, think how many that would be that are either killed or made unable to function. Luckily, Simparica Trio for dogs is considered fairly safe. Just a little nervous !! Just wondering? I want to thank everyone who posted I could not find enough information on other sites. Simparica is good at killing contagious parasites that cause mange and scabies. My precious rescue has been sick twice, currently on her second episode. Next day she seemed different, standing slightly strangely. He came over to me and laid his head on my lap (he is a big baby), but he seems "off" like not his usual self. Not drinking any water but drooling and swallowing all the time. She was shaking like she was freezing. Our two shih tzus are 6.5. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. I knew it was bad from the onset but the vet said I can't take a chance on him getting heartworms because the mosquitos are so bad not to mention fleas and ticks. I also changed him over to a raw diet a few weeks ago too have taken him off of this again to see if raw diet is causing it. Shame on you! I gave my 15 year old dog this medicine. Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. She has episodes where she seems very anxious and is hiding under car/tables/beds. She spent 4 nights at the University of Auburn emergency room and vet clinic. Seizures are going on two hours.. She was riddled with parasites when she was found as a stray, and then treated for heartworm disease just before I adopted her. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. In a wellcontrolled US field study consisting of 246 dogs administered SIMPARICA TRIO and 119 administered an active control, no dogs treated with SIMPARICA TRIO tested positive for heartworm disease. A couple of weeks later she had lost weight from not eating. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. This time he is having seizures. Just hoping you can give me something good and tell me your dog recovered. Losing my Dolly devastated me and I wanted to warn others about Simparica but I got sick. Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! He wasnt throwing up at all until he received this medication. now almost exactly two months later, sick again with a fever and stops eating. Tick titer came back a light positive which lab said was specifically false due to the recent lyme x2 booster i was scared in to giving. We go for more bloodwork today and are praying for better news. Hope your dog is doing well .my dog had clear neurological changes after taking Simparica trio .his tounge just hangs out of his mouth now and that was never the case prior to Simparica,also has tremors and shakes he never previously experienced.also major weight gain even though no increase in diet .i decided to take my pet off of simparico even though the vet strongly engouraged we remain on it even though i explained the symptoms and changes I noticed in my pet ! It really helped us to put this diarrhea condition in perspective. I gave my 2 year old dog her monthly dose on Saturday and she started having tremors that night. I hate giving her these drugs in the first place but am always convinced it is the right thing to do. We asked our vet, but he ignored the question. Seriously I have had the worse luck. He was a dog you could pick up anytime and he was good as gold. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. This is just another reason to follow your vet's recommendations for annual physical exams and tests. Billy Boy is a 9 week old Daisy Dog. Her last dose of Simparica Trio was given to her on October 1, 2021. I was using the garlic tabs for the previous dog because the vet put him on Trifexis and he vomited like crazy. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. He first started with seizures and losing weight in June after giving him Simparica. RELATED: What You Need to Know About the Lyme Vaccine for Dogs. Her protein levels dropped to almost nothing and stomach filled with fluid. I did not notice any side effects. The company is reimbursing for vet costs. I called our Vet on the second day and they said they doubted very seriously that the Simparica would have give him diarrhea, and then told me that I should wait and see what happens with the next dose, because I had also told them that he had some drippings from some ground beef over his dog food the day before I gave him that first dose. I took her home. Zoetis claims it will be out of his system in two months and I should not see lasting effects, so I am hopeful but worried and telling everyone I know NOT to use this poison. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. This month 5/1 gave him another dose and here we are 12 days later with diarrhea and no appetite. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. Bella is very consistent and normally has two bowel movements but hubby noted an increase in bowel movements and their amounts. This junk needs to be pulled from the market. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. Vet office said make sure to give with food. We rushed him to the emergency vet and they put him on keppra to stop the seizures. Im wondering if anyone else has seen these types of symptoms. Unlike Bravecto, Simparica hasn't been tested on pregnant, lactating, or breeding dogs. If fact it specifically states on the product label "Not for use in humans". I fell like hes dying right before my hands. It has been five days and the diarrhea started on day 2. I will NEVER give this drug to my dogs! So your dog got better? The vet did a nasal lavage under anesthesia and got a lot of mucus. She seems more anxious now and really attached to hubby. He started having skin issues that the vet said were allergic reactions probably due to environmental things. This medication is generally well tolerated in most pets. Why the vets use this treatment after so many side effects being reported is disgusting. Gastrointestinal issues: Some dogs may experience vomiting, diarrhea, or decreased appetite after taking Simparica Trio. Later in the fall I noticed some leg tremors when she squatted. I have an 8 year old Labrador. Over the past month she has stumbled a few times when on walks. The veterinary medicinal product should be administered at a dose of 1.2-2.4 mg/kg of sarolaner, 0.024-0.048 mg/kg of moxidectin and 5-10 mg/kg of pyrantel in accordance with the following table: Bodyweight (kg) Tablet strength 3 mg/0.06 mg/12.5 mg. Tablet strength 6 mg/0.12 mg/25 mg. I am giving her supplements to support her heart and nerves and she's a little better each day. I would notice he gets super tired walking and would go limp in my arms. Both my dogs have had runny eyes and were eating grass all summer. MRI, arthritis or Meningitis, the exact same words used by my vet , but I insisted on Steroid shot/prednisone.it has helped! Anything I can do for him? At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs). All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets), is the first once-monthly, chewable tablet that delivers all-in-one protection from heartworm disease, ticks and fleas, roundworms and hookworms. And then when we finally stop for the evening - she crashes. They then told us to follow up with a neurologist if it happened again. I just wish I could find a vet who honestly loves my animals as much as I do. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. Thank you. how long do simparica trio side effects last Author: Published on: in what way did this ruling produce a fundamental change in the united states 21 septiembre, 2020 Published in: hicks family genealogy Also vets needs to tell the truth!!! No more of this junk for my pups! Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog . He has been low energy since. Maybe? Barely eats, but is drinking lots of water. The next month, at the end of the month, I again have him his de-wormer. Im beyond heartbroken, shocked, and sad. The Vet's are so busy that even if you can get in you don't get anywhere. I will never give my dog this medication again. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. Thank you all for speaking out on Simparica Trio that Bandfield Hospital pushed on our Toy Poodle. Did you ever do an MRI or spinal tap? I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. This is so awful. I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. Its hard to say since he has previously been diagnosed with lymes. Some years back my husband gave vet approved & sold oral flea/tic medication to each of our 2 Standard Poodles. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. Her Liver enzymes were also through the roof. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. It seemed impossible that our boy could age years in literally 3 days. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. I fed him a diet of boiled chicken and rice for 3 days and began to introduce his food which is a limited ingredient type. She text me asking if she ever had seizures before. I removed it immediately She just tested positive for Lyme's. Im so upset with myself. He would come out of it when I shook him, so I didn't think anything of it at the time. We rescued another dog. The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. Oh Lord, back to finding another vet. Two weeks after first simparica dose.parasites gone. There is NO other explanation for this rapid decline and the only change has been THIS drug. It comes as the first choice when prescribing a treatment due to its liver flavor. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. Most of us dog parents use some form of heartworm prevention for our dogs. Ekko then started having seizures in May,June and July. I am convinced this medicine is HORRIBLE and is causing this. I thought right away it must be the new meds! I did and they said they are going to report it to the FDA. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. Strictly natural with zero side effects from now on. Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry. He does well on Simparica trio and also has the Lyme shot ? I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. How can it not be the Simparica that did this to my baby when nothing else changed. Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. And how do we get the word out to everyone? My dog is having the same issues. All went well until this morning. I called the vet and am putting him back on Heartgard and Nexgard. I am continuing to recover at home and have to use an oxygen tank. The only thing in his diet that really changed was his flea, tick and heartworm protection. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. I have reached out to the company but one email bounced and the other was an online form. I am not giving him his dose this month and seeing what happens. I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. Her poor top underside of her tail has raw skin the hair is completely gone like burnt off from diarrhea. The main side effect of Simparica Trio is the risk of heartworm disease in dogs. Call the FDA. Lost all appetite. He was on comfortis oral for years with no issues. After 9 days he began vomitting, even water, and mouth chattering like he was scared. There are also some rare side effects that are involved with this medication but these are very rare to and depend on the overall health of the dog as well. A growing amount of animals being treated with Bravecto, Nexgard or Simparica have experienced serious side effects, and the FDA is cautioning people that they may not be appropriate for all animals. He likely does not even have a seizure disorder- just a reaction to this de-wormer that I was assured over and over again was a great thing for him to take and couldn't possibly cause this! Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. Those jaw spasms have decreased but were pretty alarming in Dec and January. Simparico Trio, will not be given to my dog ever again. I hate that I did this to her and I hate that the Vet does not seem to care. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Company asked us to do diagnostic testing at vet. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. Hoping that these side effects dont get worse and subside soon . Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. In February, our life was upended and I forgot to give him his de-wormer. We did abx, shampoos changed food. Then giving more drugs for itching. The vet office called simparica hotline to find out if it was safe to give her another one. My baby is so sick from this Drug. What are the risks associated with Simparica? Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. I'm also wondering if his anxiety is related as well. Vet thinks it may be Addision disease and wants to test for it. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. She is now 2 1/2 months post event. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. This was January 15 of 2020. These dog training tips will help you get started. Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . Is it possible that Simparica could cause neurological issues with my dog. I've had to syringe water in his mouth. HELP!! For 5 years I have resisted my veterinarians suggestions for oral flea meds. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. I know Dukes problems were from this medicine, and it upsets me that my vet told me that this medicine was safe! Im going to keep a close watch on him over the next few days. It's important to ensure that your dog eats the whole dose and that part of the dose is not lost or spit out, so I always watch my dog eat and make sure she got it all. The next morning, she had uncontrollable tremors and could not walk without falling down. Just after the 4th dose he started to collapse at his feeding dishes on the floor, next we raised dishes and he did ok for being shaky but continued to decline to the point where he could not use dishes , and now cant eat or drink. Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. Previously B was on Heartgard and Advantix worked well I guess we switch back. 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