February 22, 2023. Adam Frost studies the molecular machines that are too fragile to purify, too large or flexible to crystallize, or are dependent on lipids that cannot be replaced by detergent micelles. Welcome to the Fraser Lab! Adam Frost's 116 research works with 6,105 citations and 14,533 reads, including: Brominated lipid probes expose structural asymmetries in constricted membranes The https:// ensures that you are connecting to the Adam Frost UCSF, US Alexandr Noy LLNL, US Alicia Alonso University of the Basque Country, ES Anjon Audhya University of Wisconsin-Madison, US Atul Parikh UC Davis, US Avital Rodal Brandeis University, US Dora Tang MPI-CBG, DE Durba Sengupta NCL, IN German Rivas CIB-CSIC, ES Harry Low Imperial College London, UK Ling-Gang Wu McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI. Adam Frost (UCSF) Butler Seminar Series. Noncontact dipole effects on channel permeation. May 4, 2016 - 12:00 pm to 1:30 pm. The N-terminus of LEM2 possesses a canonical BAF-binding LEM domain. Davidson uses a dataset of nearly 9 million anonymized patients health data and their home addresses to better understand associations between diabetes and social determinants of health or nonmedical factors that influence health outcomes, including a persons income, education and employment. In 2017, Walter and Costa-Mattioli teamed up with Susanna Rosi at UCSF, an expert on traumatic brain injuries. CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Malat1 is a Spongy RNA That Helps the Immune System Remember, Canice Christian (Global Health Sciences Program) Topic Function Follows Form: surprising insights into cell biology from the cryo-EM revolution. Membrane Constriction and Thinning by Sequential ESCRT-III Polymerization. The live event final judges were Abby Buchwalter, PhD, assistant professor at the Cardiovascular Research Institute, Dan Lowenstein, MD, the Robert B. and Ellinor Aird Professor of Neurology at UCSF; Florie Mar, PhD, global medical science director for medical affairs at Genentech and founder and president of Youreka Science; Elise Marsan, PhD, a postdoc and first prize winner of Postdoc Slam 2022; and Carla Washington, PhD, Graduate Division Alumni Association president at UCSF. LEM2 concentrates around spindle, Fig. LEM2 wets the surface of microtubules with a liquid-like coat. Our lab focuses on understanding molecular chaperone-driven protein quality control mechanisms that facilitate protein folding and cellular stress responses. Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases. The new book by Adam Frost, RHS The Creative Gardener, is published by DK, priced at 20. PMC 2022 Dec 5;221(12):e202201024. There is a remarkably integrated pipeline being developed at UCSF, with new technologies and approaches feeding off one another to advance our knowledge of the biology of disease at every level, Agard said. An Allergy Drug Showed Promise for MS. Could They Prove It? Click here for the MotionCor2 License Agreement and Download page. An official website of the United States government. Home > People > Adam Frost, PhD, MD. A Frost, R Perera, A Roux, K Spasov, O Destaing, EH Egelman, O Brandman, J Stewart-Ornstein, D Wong, A Larson, CC Williams, GW Li, DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, B Antonny, C Burd, P De Camilli, E Chen, O Daumke, K Faelber, M Ford, S Guerrier, J Coutinho-Budd, T Sassa, A Gresset, NV Jordan, K Chen, M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, C Mim, H Cui, JA Gawronski-Salerno, A Frost, E Lyman, GA Voth, PS Shen, J Park, Y Qin, X Li, K Parsawar, MH Larson, J Cox, Y Cheng, J McCullough, AK Clippinger, N Talledge, ML Skowyra, MG Saunders, R Kalia, RYR Wang, A Yusuf, PV Thomas, DA Agard, JM Shaw, A Frost, I Lax, A Wong, B Lamothe, A Lee, A Frost, J Hawes, J Schlessinger, Annual review of cell and developmental biology 34, 85-109, S Koirala, Q Guo, R Kalia, HT Bui, DM Eckert, A Frost, JM Shaw, Proceedings of the National Academy of Sciences 110 (15), E1342-E1351, Journal of neurochemistry 78 (4), 920-923. FDM 3D Printing of High-Pressure, Heat-Resistant, Transparent Microfluidic Devices. Protein synthesis. Hit 'Like' on our Facebook page, follow us on Instagram, join the conversation on Twitter and listen to our latest podcast . The Institute for Neurodegenerative Diseases is located in the Sandler Neurosciences Center on the Mission Bay campus of the University of California San Francisco. See this image and copyright information in PMC. Structural basis of membrane bending by the N-BAR protein endophilin. Email. Street San Francisco California 94158-2517 Phone: 1.415.476.3937 Fax: 1.415.476.1902 Correction of electron beam-induced sample motion is one of the major factors contributing to the recent resolution breakthroughs in cryo-electron microscopy. S412C 600 16th. Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes. government site. Read More . The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 4/17/2023 11:23 AM. Associate Professor [email protected] +1 415 514-4825. UCSF has two Titan Krios cryo-TEMs operated at 300 keV for single particle cryo-EM as well as cryo-ET each equipped with a post-column energy filter and GATAN K3 direct electron detector capable of achieving atomic level resolution structures of biological specimens with high-throughput automation and on-the-fly data processing for motion LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Search. UCSF Websites . Theres a precise point where you go from seeing rather useless blobs to being able to directly interpret a molecules structure. A proline-arginine-rich sequence within the LCD binds to microtubules and targets condensation of LEM2 to spindle microtubules that traverse the nascent nuclear envelope. Do organisms need a brain to learn? In addition to the judges award, the in-person and remote audiences voted for Rajan to receive the Peoples Choice Award. and Syst. Labs. University of California San Francisco. Business Owner Name: Adam Frost. Acknowledgements. 3 |. 1 |. Her talk on this work recently won the top prize in the 2023 UCSF Grad Slam. Contact. Adam Frost. Notably, the ability to examine the structure of proteins in their native membranes which had also been considered impossible by the field was achieved for the first time in 2016 by a close collaboration between Cheng and Julius. Click here to find our lab's preprints before peer review Languages spoken: English. Get Started. We study biomolecular machines that are too fragile to purify to homogeneity, too large or too flexible to crystallize, or that depend upon lipids for their form and function. University of California San Francisco. Structural inhibition of dynamin-mediated membrane fission by endophilin. During cell division, remodelling of the nuclear envelope enables chromosome segregation by the mitotic spindle1. National Library of Medicine E-Mail this event Share on Facebook Share on Twitter Share on Tumblr Share on Linkedin. -, Olmos Y, Hodgson L, Mantell J, Verkade P & Carlton JG ESCRT-III controls nuclear envelope reformation. The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. LEM2 promotes early nuclear compartmentalization via cooperation between its LCD, Extended Data Fig. doi: 10.1083/jcb.202201024. adam.frost@ucsf.edu. mRNA export, RNA splicing and turnover. Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens. Altos Labs, University of California, San Francisco, University of Utah. An Extra Nudge in the Direction of Cancer, Benjamin Wheeler (Biomedical Sciences Program) B. in Physics. PMID: 32494070 PMCID: PMC7321842 DOI: 10.1038/s41586-020-2232-x Abstract During cell division . We Have the Power to Stop HIV. Epub 2022 Oct 7. UC San Francisco researchers recently captured exquisite images of a protein caught in the act of binding to a novel therapeutic drug with enough resolution to model how the individual atoms of the protein and drug lined up. 2021 Jul 21;10:e59999. San Francisco, CA 94158. Epub 2022 Oct 27. He obtained a PhD in Clinical Psychology at Palo Alto University, with an emphasis in neuropsychology. Furthermore, the winged-helix domain of LEM2 activates the ESCRT-II/ESCRT-III hybrid protein CHMP7 to form co-oligomeric rings. The LEM motif of LEM2 binds BAF, conferring on LEM2 an affinity for chromatin5,6, while an adjacent low-complexity domain (LCD) promotes LEM2 phase separation. Before -, Gu M et al. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. February 23, 2022 - Adam Frost (UCSF) Membrane-Associated Quality Control Mechanisms . Archambault V, Li J, Emond-Fraser V, Larouche M. Front Cell Dev Biol. Activated CHMP7 forms polymeric rings via its ESCRT-III domain, exposing, Extended Data Fig. English, Departments: Participating in Grad Slam has been an amazing opportunity to exercise and grow my communication skills, Teter said. New Website Checklist; Quiz: Do I Need A Website? Learn about UCSFs response to the coronavirus outbreak, important updates on campus safety precautions, and the latest policies and guidance on our COVID-19 resource website. Sending the Right Signal How Cells Talk to and Interpret Each Other, Victoria Sayo Turner (Neuroscience Program) LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. January 26, 2022 - Andreas Martin (University of California, Berkeley) . Make sure that the humidity control is on since the default for startup seems to be off. Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. sharing sensitive information, make sure youre on a federal . Ribosome-associated quality control and CAT tailing. Exactly how Stentor learns without a brain is a question that Deepa Rajan, a graduate student in UC San Franciscos Tetrad Graduate Program, is trying to answer. Search form. Please enable it to take advantage of the complete set of features! UCSF graduate programs were among the first in the country to break down traditional barriers between departments and disciplines, and interdisciplinary thinking permeates the program curriculum and faculty. 2021-12-06 | Preprint. We would like to show you a description here but the site won't allow us. Contact us, 2023 The Trustees of Princeton University. Elife. Federal government websites often end in .gov or .mil. This site needs JavaScript to work properly. Membrane trafficking: decoding vesicle identity with contrasting chemistries. 2022 Oct 4;10:1012768. doi: 10.3389/fcell.2022.1012768. He completed a clinical internship at the West Los Angeles VA Health Care System and a two-year postdoctoral . Contributors : Lan Wang; Morgane Boone; Rosalie E Lawrence; Adam Frost; Peter Walter; Michael Schoof. WATCH: Gardeners' World presenter Adam Frost gives a tour of his stuninng garden. The overarching goal of the IND is to develop drugs that stop prion accumulation and thus halt neurodegeneration. Is there additional information on UCSF websites that would be helpful to you? Structural basis of membrane deformation by the ESCRT-III family of proteins (107.4). Research in the lab is focused on discovering the fundamental principles of macromolecular structure and dynamics. Over the past few years, there has been a remarkable and expanding consensus that many- if not all- neurodegenerative diseases are due to the accumulation of prions. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM. Until recently, such a feat would have been considered impossible, but in the past five years, such breakthroughs have become almost commonplace here, part of a resolution revolution being led by UCSF researchers. 8 |. and transmitted securely. Im really grateful to have received two awards, and it is a testament to the support I have received at UCSF, Rajan said. Keck Foundation Advanced Microscopy Laboratory is located at the Misson Bay Campus of the University of California at San Francisco. My English Home: Monty Don. Set blot time, force, wait time, blot total (remember to set it to "1". He then received a masters in physics from UCLA in 2004, before moving to the University of . A Tunable Microfluidic Device Enables Cargo Encapsulation by Cell- or Organelle-Sized Lipid Vesicles Comprising Asymmetric Lipid Bilayers. 5F- and 6F-Trp gramicidin channel currents. UCSF EMCore - high-resolution structures & high-throughput - By using image-shift data collection, we've achieved physical Nyqvist frequency using our high magnification data collection settings and beyond (> 150%) physical Nyqvist frequency using our lower magnification settings. Adam Frost, UCSF. MS notes - usually blot force 3 and blot time 8 sec work for . The Omicron Effect: Can We Predict the Next Viral Killer. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. Burla R, La Torre M, Maccaroni K, Verni F, Giunta S, Saggio I. Nucleus. Frost Share Event. She took home $4,000 for first prize and $750 for the Peoples Choice Award. Associate Professor. A panel of judges voted for Rajan as the first-prize winner. eIF2B conformation and assembly state regulates the integrated stress response. Would you like email updates of new search results? The W.M. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. 2 |. Dr. Staffaroni is a neuropsychologist and assistant professor at the UCSF Memory and Aging Center. All others are required to contactDavid Agardfor licensing information prior to download. [3] He started his career working for North Devon Parks Department and then he moved to London, to work as a landscaper. Altos Labs is a new life science company focused on cellular rejuvenation programming to restore cell health and resilience, with the goal of reversing disease to transform medicine. Endosis and exosis: new names for fusion and budding. 94143. But at UCSF, the culture nurtures us to do things that everybody else thinks are impossible.. BioArxiv:http://biorxiv.org/content/early/2016/07/04/061960, More details please refer to UCSF Macromolecular Structure Group - Software, 2023 The Regents of the University of California, http://biorxiv.org/content/early/2016/07/04/061960, UCSF Macromolecular Structure Group - Software, Nature Methods, 10, 584-590. We seek to understand how fuel-driven biological machines work, especially those too . Homology modeling and crosslinking-mass spectrometry (XL-MS) consistent with a WH, Extended Data Fig. PMID: 20558298. Gatta AT, Olmos Y, Stoten CL, Chen Q, Rosenthal PB, Carlton JG. It also made possible discoveries in Agards lab about proteins that help other proteins maintain their proper shape, a process that has major implications for cancer and diseases such as Alzheimers disease that are characterized by misshapen proteins. Mechanistic Insights into Membrane Remodeling Through BAR-Domain Proteins. The BAR domain superfamily: membrane-molding macromolecules. Highly Innovative and Constantly Evolving Curriculum. 2023 The Regents of the University of California. 17 Oct 2022. Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. frost@biochem.utah.edu (415) 514-4825 UCSF - Professor Adam Frost - Dept. Facility Access & Rules; Scheduling & iLab; FEI T12 TEM; FEI T20 TEM; Talos Arctica Cryo-TEM; Glacios Cryo-TEM; Aquilos 2 Cryo-FIB; Titan Krios Cryo-TEM; Documents. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A. Proc Natl Acad Sci U S A. Prior to the discovery of their membrane-remodeling properties, BAR domains were identified as conserved modules shared by the yeast proteins Rvs161 and Rvs167 (reduced viability upon starvation) and the metazoan amphiphysin/BIN (bridging interactor) proteins (Takei et al., 1999, Farsad et al., 2001, Peter et al., 2004).Fifteen eukaryotic crystal structures from the superfamily have now been . Our lab strives to see how molecules get together and come to life. Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis. He is also jointly appointed with the Departments of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology at UCSF. This pruning of synapses is normal and necessary to form specialized neural circuits. All Rights Reserved.Department of Molecular Biology, Assistant Professor, Biochemistry and Biophysics, Free and open to the university community and the public, Fred Hughson, Department of Molecular Biology, Genetics and Molecular Biology Training Grant, Genome Editing Shared Resource (Rutgers-CINJ), Glenn Center For Quantitative Aging Research, Lewis-Sigler Institute for Integrative Genomics. Cell biology: Double agents for mitochondrial division. Rose M, Burgess JT, O'Byrne K, Richard DJ, Bolderson E. Cancer Metastasis Rev. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Structural and functional studies of membrane remodeling machines. Discussion Leader: Adam Frost (Altos Labs & UCSF, United States) 7:30 pm - 7:45 pm: Introduction by Discussion Leader. Protein folding in vivo, protein sorting, and macromolecule dynamics. Thomas Laboratory 003. LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation. of Comp. Unauthorized use of these marks is strictly prohibited. She identified a signal that microglia use to find synapses and showed that neurodevelopmental disorders can hijack this signal. University of California, San Francisco. Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Electron-counting cameras really provided a quantum leap in our ability to understand a proteins underlying chemistry both how it functionsand how you could design drugs that bind to it.. Frost Dr. Adam Frost, UCSF, will deliver a virtual seminar on Tuesday February 16th, 2021. Science (New York, N.Y.) 48. Verified email at ucsf.edu - Homepage. We propose that during nuclear reassembly LEM2 condenses into a liquid-like phase and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin and the spindle. Epub 2015 Sep 11. Winning second prize at Grad Slam showed me that I am walking in the right steps of using my gift to communicate my science to the masses in the future, Davidson said. It's a c. Gardeners' World presenter Adam Frost has been a regular face on the BBC for many years now, having presented the popular horticultural show since 2016 as well as the channel's coverage of the RHS . 5 |. . UCSF researcher Adam Frost takes you on a tour from his home in Mill Valley, CA, to his lab at UCSF's Mission Bay campus in beautiful San Francisco. GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control. -, Vietri M et al. We are interested in studying the three-dimensional structures of macromolecular complexes: their structural architectures, the regulation of their function and the dynamic processes of their assembly and disassembly, by molecular electron microscopy (cryoEM). Academic Information. Extended Data Fig. 2017 Mar 14;114(11):E2166-E2175. San Francisco, CA. Learning Without a Brain - Deepa Rajan He is most known for his achievements at the Chelsea Flower Show and for his role as a presenter on the BBC program Gardeners' World. This cryo-EM renaissance was spurred by Agard and Chengs efforts to develop camera hardware and software capable of detecting single electrons a goal that had long been considered impractical by the field, but which the duo accomplished by bringing together scientists and engineers at UCSF, Lawrence Berkeley National Laboratory, and Gatan, a Pleasanton, Calif., company that makes EM cameras. Practical Considerations of Using the K3 Camera in CDS Mode for High-resolution and High-throughput Single Particle Cryo-EM. Want more information and inspiration from The English Home? The 10 finalists were selected by a panel of screening judges who reviewed more than 30 initial video entries. UCSF EM Core Facility . Lowenstein told the student finalists, Listening to all these talks is so inspiring because of the way your work is going to translate into improving the lives of the people who come to seek health care at UCSF. The single-celled organisms eventually habituate to the tapping and stop responding. The other finalists in this years competition, in order of appearance, were: Sophia Guldberg (Biomedical Sciences Program) Membrane fission by dynamin: what we know and what we need to know. UCSF Profiles is UCSF's version of the ground-breaking, open source "Profiles Research Networking Software" that was developed under the supervision of Griffin M Weber, MD, PhD, with support from Grant Number 1 UL1 RR025758-01 to Harvard Catalyst: The Harvard Clinical and Translational Science Center from the National Center for Research Resources and support from Harvard . Membrane constriction and thinning by sequential ESCRT-III polymerization. PMID: 23644547. UCSF News. Structural basis of mitochondrial receptor binding and constriction by DRP1. Disclaimer. Livestream Information Zoom February 16, 2021 (Tuesday) 12:00pm Meeting ID: 96151442305. Memoirs of a Worm, Saumya Bollam (Biomedical Sciences Program) This years event was held in person at Genentech Hall at Mission Bay and streamed live on YouTube. yifan.cheng@ucsf.edu +1 415 514-9708 We are interested in studying the three-dimensional structures of macromolecular complexes: their structural architectures, the regulation of their function and the dynamic processes of their assembly and disassembly, by molecular electron microscopy (cryoEM). Regulation of transcription and translation. This unrestricted funding gives Investigators the freedom to pursue their most exciting, visionary ideas, many of which involve the invention of new tools and . Loss of function of the nuclear envelope protein LEMD2 causes DNA damage-dependent cardiomyopathy. Electron Cryo-Microscopy; Structural Biology; Membrane Biology; Cell . Frost Lab at UCSF. Rajan was one of 10 graduate student finalists competing in this years UCSF Grad Slam held on April 4, in which students presented their research in three minutes or less in terms easily understood by a general audience. Adam Frost is a well-known British garden designer who was born in September 1969. Nat Rev Mol Cell Biol 18, 229245, doi:10.1038/nrm.2016.153 (2017). Deepa Rajan presents her winning talk, Learning Without a Brain. Watch the full 2023 Grad Slam. Learn more, Researchers Are Pushing the Boundaries of Nobel-Winning Technology to Better Understand Human Health. The New Website for the Frost Lab - built on Jekyll for Github Pages and modelled loosely off of the website of the Fraser Lab. Extended Data Fig. Thermo Fisher Scientific Opens Cell Therapy Facility at UCSF to Accelerate Development of Breakthrough Therapies. Proteins are tiny molecular machines that power everything our cells do and they are also the primary targets for pharmaceutical drugs. 2015 Jun 11;522(7555):231-5. doi: 10.1038/nature14408. But to truly understand how proteins function, researchers must be able to visualize them at an atomic scale. of Biochemistry & Biophysics, Office of Health Equity, Diversity, & Inclusion, University Health Equity, Diversity, & Inclusion. Welcome to the Frost lab.We are a part of Altos Labs and work at the San Francisco Bay Area Institute of Science.We are affiliated with the Chan Zuckerberg Biohub, the University of Utah, and the University of California, San Francisco. Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H. Nature. UCSF Site Builder; Custom-Built Sites; Website Hosting; . 7:45 pm - 8:00 pm: Jeanne Stachowiak (The University of Texas at Austin, United States) "Flexible Protein Networks Organize and Remodel Membranes During Clathrin-Mediated Endocytosis" Its not just a matter of seeing proteins a little more clearly, Agard explained. Otherwise, it won't blot); Click the checkbox of "humidifier off during process" and "skip grid transfer". Cryo-EM is now allowing us to study proteins at a level of detail that would never have been possible just a few years ago, Frost said. July 3, 2019 : Adam Frost lab at UCSF setup using Oculus Rift S headset to analyze high resolution cryoEM maps. Adam Frost's Phone Number and Email Last Update. The same patients also waited longer to visit the doctor than patients from higher-income neighborhoods. Accessibility The integrated stress response (ISR) is activated by phosphorylation of the translation initiation factor eIF2 in response to various stress conditions. 6 |. Gardeners' World star Adam Frost might be known for his successes at the RHS Chelsea Flower Show, but there's something else he is passionate about: his two gorgeous dogs, Isla and Mo. 8600 Rockville Pike Daniel Southworth, PhD. Adam Frost is a Position In Membrane-Associated Quality Control Mechanisms at UCSF Health based in San Francisco, California. After beginning his professional life working for the North Devon Parks Department, he then relocated to London and began a . 8 Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA. California San Francisco, San Francisco a WH, Extended Data Fig Cancer, Benjamin Wheeler ( Sciences. For Neurodegenerative Diseases is located at the West Los Angeles VA Health Care System a... 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