Which is better for summer heat? 2013;4(3):368s-377s. 1967 Jan 16;199 (3):215-7. doi: 10.1001/jama.199.3.215. 2012;4:2097-120. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. The information on dietary factors and supplements, food, and beverages contained on this website does not cover all possible uses, actions, precautions, side effects, and interactions. Learn how we can help WebPotassium Citrate and Potassium Gluconate Versus Potassium Chloride: Experimental Evaluation of Relative Intestinal Toxicity Scott J. Boley, MD ; Leon Schultz, MD ; Solomon Schwartz, MD ; et al Armand Katz, MD ; Arthur C. Allen, MD Adults and teenagers20 mEq mixed in 2 tablespoonfuls or more of cold water or juice taken two to four times a day. Since muscle activity controls numerous bodily activities, this mineral is important for a variety of normal body functions, including digestion. Citrate uses a differnt salt. Created for people with ongoing healthcare needs but Drug information provided by: Merative, Micromedex. I've been treated for multiple myeloma for 10 years. Potassium citrate is useful in maintaining normal cardiac rhythm and blood pressure 3. Both may be used to. Too much potassium is Would you like email updates of new search results? Note 2. Your doctor may prescribe potassium citrate if you have a mild urinary tract infection, such as cystitis. I have been drinking 11.5 oz low sodium V-8 every day for years. Expression of osteoporosis as determined by diet-disordered electrolyte and acid-base metabolism. (PubMed), 20. Clausen T. Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: functional significance. Is NyQuil (Or DayQuil) Safe To Take With Paxlovid? Additionally, a pooled analysis of the data from all three cohorts showed that those with the highest versus lowest animal protein-to-potassium ratio were 41% more likely to develop kidney stones (21). 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). It helps maintain the water balance inside the cells and is essential in the transmission of nerve impulses. Mucinex Vs. Mucinex D vs. Mucinex DM: What Is The Difference? The Dietary Reference Intakes (DRIs) for potassium have been recently revised by the Food and Nutrition Board (FNB) of the National Academy of Medicine. Dietary sodium: a therapeutic target in the treatment of hypertension and CKD. Take this medicine only as directed by your doctor. Potassium is an essential mineral found in various foods. Potassium Gluconate It is the potassium salt of the conjugate base of gluconic acid (an organic compound) that is made from glucose (sugar) by fermentation and subsequent neutralization with a potassium source. 2018;137(3):237-246. HHS Vulnerability Disclosure, Help The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Experimental evaluation of relative intestinal toxicity. 2001;39 Suppl 2:33-36; discussion 36-37. Bottom Line Potassium Gluconate vs Potassium Chloride The main differences between the two medicines are that the KCI is given if there are low levels of both chloride and potassium in the blood, while KG is given to patients as a supplement if he has a healthy chloride level. 2015;26(4):1311-1318. 2018;319(12):1209-1220. Potassium citrate: treatment and prevention of recurrent calcium nephrolithiasis. Potassium chloride is used as a supplement to raise potassium levels in your body. information is beneficial, we may combine your email and website usage information with We answer our latest question regarding the difference between dietary potassium from foods and potassium medication to treat hypokalemia (low potassium). Nutr Today. Potassium chloride and potassium gluconate are both used to treat and prevent hypokalemia. other information we have about you. All rights reserved. Potassium gluconate is alkaline (compared to potassium chloride, which is acidic). Eating a diet with enough potassium can help prevent diseases and conditions, such as stroke, hypertension, osteoporosis and kidney stones, according to the Linus Pauling Institute. Adults and teenagers15 milliequivalents (mEq) mixed into one-half glass of cold water or juice, taken three or four times a day. 1998;339(7):451-458. Select one or more newsletters to continue. Potassium concentrations are about 30 times higher inside than outside cells, while sodium concentrations are more than 10 times lower inside than outside cells. Accessibility Copyright 2023 YOUR HEALTH REMEDY. Potassium is a normal component of a regular, well rounded diet and is contained in many foods such as meats, fruits and vegetables. 2018;53(5):184-195. Do not chew or suck on the tablet. Potassium citrate acts as a diuretic (making you pee more), and is used to manage, prevent or treat conditions such as: Potassium gluconate may be used to manage, prevent or treat low potassium levels (hypokalemia). Linus Pauling Institute Curhan GC, Willett WC, Rimm EB, Stampfer MJ. So once you are back in your normal range, it may be worth discussing with your doctor if a possible option is to stop supplementation and see if your dietary intake of the V-8 is sufficient to prevent low potassium from occurring again. As an electrolyte, potassium is involved in transporting nutrients to the cells and carrying wastes away. Lack of potassium may cause muscle weakness, irregular heartbeat, mood changes, or nausea and vomiting. In contrast, a two-year randomized controlled trial found that neither supplementation with potassium citrate (721 mg/day or 2,165 mg/day) nor an increase in fruit and vegetable intake (300 mg/day) had an impact on markers of bone turnover or increased BMD in postmenopausal women (30). Call your doctor or 911 if you think you may have a medical emergency. However, insufficient dietary potassium in patients at risk of hypokalemia can precipitate hypokalemia (1). Epub 2016 Nov 10. The purpose is to alleviate nighttime leg cramps. CUA guideline on the evaluation and medical management of the kidney stone patient - 2016 update. For long-acting oral dosage forms (liquid for solution): Adults and teenagers20 mEq mixed into one-half glass of cold water or juice, taken one to four times a day. Finally, many salt substitutes contain potassium chloride, and acesulfame potassium (Ace-K) is an FDA-approved general purpose sweetener. N Engl J Med 1993;328:833-8. It maintains proper muscle and nerve function, is involved in metabolic processes, and helps control blood pressure. Its formula is: c6h11ko7. Adults and teenagers20 milliequivalents (mEq) diluted in 2 tablespoonfuls or more of cold water or juice, taken two to four times a day. Gennari FJ. Certain diseases or medications can cause potassium levels to drop to unsafe levels. (PubMed). I suspect the differences are in dosage an tolerability. Epub 2013 May 29. A prolonged bout of vomiting or diarrhea can also cause hypokalemia. Tylenol Arthritis Vs. Tylenol Extra Strength: What Is The Difference? Three large US prospective cohort studiesthe Health Professionals Follow-up Study and the Nurses Health Studies I and IIwhich included 193,676 participants, have examined dietary potassium intake and animal protein-to-potassium ratio (a marker of dietary acid load) in the diet in relation to the risk of developing kidney stones (21). If a physician writes for metformin ER, is it legal to dispense the generic form of Glumetza, Fortamet, or Glucophage XR? Urology. Meta-analyses have also reported a dose-response relationship between the intake of potassium and the lowering of blood pressure (42, 43). Similarly, a 2016 clinical trial evaluated potassium levels with glucose and diabetes risk over eight years. Available at: https://www.cdc.gov/bloodpressure/facts.htm. 1. What is the difference between the Apadaz and hydrocodone products like Vicodin and Norco. Potassium citrate may also be used for other purposes other than those listed in this medication guide. Sodium and potassium intake: effects on chronic disease outcomes and risks. Potassium comes in a few different forms, including potassium citrate and potassium gluconate. Portions of this document last updated: April 01, 2023. If you have kidney dysfunction, or are on certain types of medication such as potassium-sparing diuretics however, it is important to be mindful of taking in too much potassium.. Your doctor may change the dose if needed. (PubMed), 37. Washington, D.C.: National Academies Press; 2005:186-268. You may hyperlink to this website but must include the following statement: "This link leads to a website provided by the Linus Pauling Institute at Oregon State University. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. June 26, 2018. The richest sources of potassium are fruit and vegetables. Moreover, avoid these supplements if you: Interaction with alcohol is unknown, thus, stay on the safe side and avoid alcoholic beverages while using these supplements. ChildrenDose is based on body weight and must be determined by your doctor. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Your body uses potassium to help your heart, muscles, kidneys, nerves and digestive system work properly. Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial. Weaver CM. Adler AJ, Taylor F, Martin N, Gottlieb S, Taylor RS, Ebrahim S. Reduced dietary salt for the prevention of cardiovascular disease. In all three cohorts, dietary potassium intake was derived almost entirely from potassium-rich foods, such as fruit and vegetables. Potassium plays an important role in maintaining the health of your kidneys, heart, muscles, and nervous system. the unsubscribe link in the e-mail. 1997 Apr;313(4):215-9. doi: 10.1097/00000441-199704000-00004. Jackson SL, Cogswell ME, Zhao L, et al. Her work has been published in "Prevention," "Nurseweek" and "Senior Life." Stone M, Martyn L, and Weaver C. Potassium intake, bioavailability, hypertension, and glucose control. N Engl J Med. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Normally the kidneys remove excess potassium from the body but when there is kidney disease, high levels of potassium can affect the hearts functions. Urinary saturation of calcium oxalate and brushite decreased but not as much as the decrement in urinary calcium because of reduced citrate-calcium complexation. Both supplements effectively treat hypokalemia (low blood levels of potassium). Fenton TR, Eliasziw M, Lyon AW, Tough SC, Hanley DA. Although these observational studies suggest a link between potassium intakes and bone health, they cannot establish whether there is a cause-and-effect relationship. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Overall: As you can see here, there is far more elemental potassium in potassium chloride than there is in potassium gluconate. Keep from freezing. Penicillins: penicillin G sodium (Pfizerpen), mezlocillin (Mezlin), carbenicillin (Geocillin), ticarcillin (Ticar), Loop diuretics: bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), torsemide (Demadex), Thiazide diuretics: Acetazolamide, thiazides, chlorthalidone (Hygroton), indapamide (Lozol), metolazone (Zaroxolyn), chlorothiazide (Diuril), fludrocortisone (Florinef), hydrocortisone (Cortef), cortisone (Cortone), prednisone (Deltasone), Substances with mineralocorticoid effects: licorice, carbenoxolone, gossypol. Urinary alkalinization with supplemental potassium citrate is used in stone formers to reduce the risk of recurrent stone formation (reviewed in 22). Morris RC, Jr., Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A. If you take 20 MEQ of POT chloride and run out it states that 8.5 tablets of POT glu is equal to 10 MEQ of POT Chloride. Cochrane Database Syst Rev. These may not be safe for people with certain conditions, such as kidney disease or heart disease. Conversely, potassium deprivation has been found to increase urinary calcium excretion (19, 20). This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Potential side effects of potassium citrate and potassium gluconate include: Taking a lower dose of potassium citrate or potassium gluconate can help dissipate these side effects. The information should not be used in place of a consultation with a competent health care or nutrition professional. (PubMed), 8. The best electrolyte products use potassium chloride. For patients taking the liquid form of this medicine: For patients taking the soluble granule, soluble powder, or soluble tablet form of this medicine: For patients taking the extended-release tablet form of this medicine: For patients taking the extended-release capsule form of this medicine: Take this medicine immediately after meals or with food to lessen possible stomach upset or laxative action. Moreover, taking potassium D-gluconate might help support the health of the bones since this mineral makes up a small component of the bone tissue, forming the compound in the bones responsible for bone density. Potassium is available in different supplemental forms, including potassium chloride, potassium citrate, potassium gluconate, potassium bicarbonate, potassium aspartate, and potassium orotate (50). WebPotassium Citrate and Potassium Gluconate Versus Potassium Chloride: Experimental Evaluation of Relative Intestinal Toxicity | JAMA | JAMA Network IN LATE 1964 a sudden increase in the occurrence of circumferential ulcerating, stenosing lesions of the small bowel was noted both in Europe and the United Sta [Skip to Navigation] Oncologist Rx'd potassium chloride capsules, 600 mg (8 MEq). Thus, the ability of thiazide to lower the urinary saturation of calcium oxalate was accentuated by potassium citrate supplementation but not by potassium chloride supplementation, probably owing to increased citrate complexation of calcium. Our body regulates potassium concentrations to achieve a certain level both inside and outside the cell but, for variety of reasons, that concentration can either go too high (hyperkalemia) or too low (hypokalemia). Both potassium citrate and potassium gluconate may be used as food additives or supplements, but they have some slightly different applications. Swallow the capsule whole with a full (8-ounce) glass of water. In this study, the highest versus lowest quartile of urinary potassium excretion (mid-values, 3,043 mg/day versus 1,484 mg/day) was associated with a 62% lower risk of hypertension (37). Linus Pauling Institute Various mechanisms explain how certain medications can lead to potassium depletion. Potassium citrate forms white or transparent crystals, while potassium gluconate forms yellowish white granules. Am J Clin Nutr. As medications, potassium citrate and potassium Gitelmans (GS) and Bartters (BS) syndromes are rare, inherited autosomal recessive tubulopathies characterized by hypokalemia, metabolic alkalosis, renal sodium, chloride, and potassium and magnesium-wasting. Potassium gluconate, a chemical combination of potassium and glucose, is one of the most frequently prescribed minerals. Potassium citrate and potassium chloride can cause allergic reactions in some people. https://pubchem.ncbi.nlm.nih.gov/compound/13344, https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=FoodSubstances&id=POTASSIUMGLUCONATE, https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=FoodSubstances&id=POTASSIUMCITRATE, https://www.fda.gov/food/food-additives-petitions/food-additive-status-list, https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019071s012lbl.pdf, Potassium Citrate Information for Consumers, Potassium Citrate Information for Healthcare Professionals, Renal tubular acidosis (when the kidneys do not properly remove acids from the blood), Kidney stones (crystal-like formations in the kidneys). Potassium chloride, as a prescription, is measured in mEq ormilliequivalents. Potassium electrolyte helps the muscles to contract or relax by controlling the transport Broccoli. However, most people will not take more than 100 mEq a day. Dietary Reference Intakes for Sodium and Potassium - uncorrected proofs. (PubMed), 36. The usual dose is 2 to 3 mEq per kg (0.9 to 1.36 mEq per pound) of body weight taken in smaller doses during the day. Potassium comes in a closed container at room temperature, away from heat, moisture, and glucose is. Potassium depletion ( 8-ounce ) glass of water an FDA-approved general purpose sweetener inside the cells and wastes! Evaluation and medical management of the most frequently prescribed minerals teenagers15 milliequivalents mEq... Is essential in the treatment of hypertension and CKD as determined by your doctor may prescribe citrate... Are fruit and vegetables, Rimm EB, Stampfer MJ to help your heart,,. ) is an FDA-approved general purpose sweetener an important role in maintaining normal cardiac rhythm and pressure. Decrement in urinary calcium excretion ( 19, 20 ) for people with healthcare. 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